The Greatest African Adventure with Mistral Travel: a luxury safari and beach getaway in Kenya

Mistral Travel announces a 11-day Luxury Kenya Safari and Beach Experience, combining thrilling wildlife safaris in the Masai Mara with serene relaxation on Diani Beach. The journey includes luxurious accommodations, expert guides, gourmet dining, and personalized service. Travelers will explore the Big Five in their natural habitat and enjoy activities like snorkeling and spa treatments. This exclusive adventure offers the perfect blend of adventure and relaxation, with a focus on safety and comfort. Sofia, Sofia-city, Bulgaria, 12th Aug 2024 - SOFIA, BULGARIA - Mistral Travel is thrilled to announce an unparalleled luxury experience with its exclusive Kenya Safari and Beach package for the period 29.01.2025 - 08.02.2025. This meticulously curated 11-day journey combines the thrill of African wildlife safaris in the legendary Masai Mara with the serene beauty of Diani Beach, offering travelers the perfect blend of adventure and relaxation (in bulgarian is екскурзия до Кения).Journey HighlightsDay 1-2: Arrival in Nairobi Travelers will begin their adventure in Nairobi, Kenya’s bustling capital. Upon arrival, guests will be accommodated in a luxurious hotel, offering a comfortable and relaxing start to the journey. This initial stop provides an opportunity to acclimate and prepare for the exciting days ahead.Day 3-5: Masai Mara Safari The adventure truly begins as travelers are whisked away to the world-renowned Masai Mara National Reserve. Known for its rich wildlife and stunning landscapes, the Masai Mara is a haven for nature enthusiasts and photographers. Guests will stay in luxurious safari lodges that blend comfort with the authentic safari experience. Daily game drives will provide opportunities to witness the Big Five (lion, leopard, elephant, buffalo, and rhino) in their natural habitat, along with countless other species of wildlife.Day 6-11: Diani Beach After the excitement of the safari, the journey continues to the pristine beaches of Diani. This coastal paradise is famous for its white sandy beaches, crystal-clear waters, and lush palm trees. Guests will stay in a luxurious beach resort, where they can indulge in various activities such as snorkeling, diving, and spa treatments. Diani Beach is also an excellent location for deep-sea fishing and exploring the vibrant marine life of the Indian Ocean.Day 12: Departure The journey concludes with a return to Nairobi for the departure flight. Travelers will leave Kenya with unforgettable memories and a deep appreciation for the country's diverse landscapes and wildlife. Exclusive Features and BenefitsLuxury Accommodations Throughout the journey, guests will enjoy top-tier accommodations that provide the perfect blend of comfort and authenticity. From luxurious safari lodges in the Masai Mara to a beachfront resort in Diani, every stay is designed to offer the utmost relaxation and convenience.Personalized Service Mistral Travel prides itself on providing personalized service to each traveler. The dedicated team ensures that every aspect of the journey is tailored to meet the needs and preferences of the guests, from dietary requirements to special requests.Expert Guides The safari experience is enhanced by the presence of expert guides who have an in-depth knowledge of the local wildlife and ecosystems. Their insights and expertise provide a deeper understanding of the natural wonders encountered on the journey.Gourmet Dining Culinary experiences are an integral part of the journey, with gourmet meals prepared using the finest local ingredients. Whether dining in the wild during a safari or enjoying a beachfront dinner, each meal is crafted to delight the senses.Safety and Comfort Safety is a top priority for Mistral Travel. All accommodations and activities adhere to the highest safety standards, ensuring that guests can enjoy their adventure with peace of mind. Booking InformationThe Luxury Kenya Safari and Beach Experience is available for booking now. Interested travelers are encouraged to visit the Mistral Travel website for detailed itineraries and pricing information. Early booking is recommended to secure a spot on this exclusive journey. About Mistral TravelMistral Travel is a Bulgarian premier travel agency specializing in luxury travel experiences around the world. With a commitment to excellence and personalized service, Mistral Travel creates unforgettable journeys that cater to the unique desires and needs of each traveler. From bespoke safaris to serene beach holidays, Mistral Travel offers a wide range of meticulously planned itineraries designed to provide the ultimate travel experience.Contact: Mistral TravelPhone: +359 2 980 33 22Email: info@mistralbg.comWebsite: www.mistralbg.comMistral Travel Office 1 - Google mapsMistral Travel Office 2 - Google maps Media Contact Organization: Mistral Travel Bulgaria Contact Person: Boris Karageorgiev Website: https://www.mistralbg.com Email: Send Email Contact Number: +35929803322 Address:Office 1: Sofia Center, 29 Buzludzha str., fl.1, office 2 Address 2: Office 2: Sofia, Studentski area, 6 Prof. Georgi Bradistilov str., mag. 1 City: Sofia State: Sofia-city Country:Bulgaria Release id:15332

LeadGenerator.at Revolutionizes New Customer Acquisition with Personalized Video Messages

Austria, 10th Aug 2024, King NewsWire – LeadGenerator.at is setting a new standard in customer acquisition with its innovative platform tailored specifically for marketing, web design, and SEO agencies. This groundbreaking solution enables companies to deliver up to 1,000 personalized video messages to potential customers, providing a unique and engaging way to connect and offer actionable insights. In today’s competitive digital landscape, distinguishing oneself from the competition is essential. LeadGenerator.at offers a transformative approach, allowing agencies to capture attention and stand out through personalized video messages that simulate a real-time analysis of the recipient’s website. This feature not only enhances engagement but also delivers valuable suggestions for improvement, demonstrating the agency’s expertise in a compelling manner. How It Works: Target Selection: Agencies choose their target customers. Video Creation: LeadGenerator.at generates personalized video messages for each potential customer. Live Analysis: The videos simulate a live analysis of the recipient’s website, offering actionable tips for enhancement. Maximizing ROI Through Targeted Communication “Our platform ensures an exceptional return on investment for agencies,” says Peter Mayer, CEO of LeadGenerator.at. “By leveraging highly personalized and interactive communication, we achieve open and conversion rates significantly higher than the industry average.” Key Benefits for Agencies: Increased Attention: The innovative presentation method garners greater interest from potential customers. Expertise Showcase: Agencies can clearly demonstrate their expertise through the personalized video content. Time Efficiency: The platform automates the creation and delivery of up to 1,000 video messages, saving valuable time. Scalability: Reach a larger audience in less time, enhancing overall marketing  LeadGenerator.at is specifically designed to cater to a diverse range of digital professionals. This includes digital marketing agencies, web design studios, SEO specialists, and online marketing consultants. By offering a tailored approach to customer acquisition, LeadGenerator.at provides these professionals with the tools needed to enhance their outreach efforts and engage potential clients more effectively. The Future of New Customer Acquisition As traditional cold calling becomes increasingly ineffective, LeadGenerator.at offers a forward-thinking alternative that combines the benefits of personalized communication with the efficiency of automation. “We’ve observed that potential customers respond exceptionally well to the tailored analysis of their website,” Mayer adds. “This innovative approach opens new avenues for engagement and conversion.” For more information about how LeadGenerator.at can transform your customer acquisition strategy, please visit LeadGenerator.at or contact: Peter MayerCEO, LeadGenerator.atEmail: Peter@LeadGenerator.at About LeadGenerator.at: LeadGenerator.at is a pioneering platform developed in Austria to enhance customer acquisition for marketing, web design, and SEO agencies. By providing a unique, personalized approach to customer engagement through video messages, LeadGenerator.at helps agencies stand out and drive better results in their outreach efforts. Media Contact Organization: LeadGenerator.at Contact Person: Peter Mayer Website: https://leadgenerator.at/ Email: Send Email Country: Austria Release Id: 10082415502 The post LeadGenerator.at Revolutionizes New Customer Acquisition with Personalized Video Messages appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

Why Galaxy Plumbing & Heating is Vancouver's First Choice for Emergency Plumbing

Imagine waking up in the middle of the night to the sound of water gushing through your home. A burst pipe has turned your peaceful haven into a potential disaster zone. In such moments, every minute counts, and the importance of a reliable emergency plumbing service becomes crystal clear. Plumbing emergencies like these can cause extensive damage quickly, leading to costly plumbing repairs, disrupted routines, and, in worst-case scenarios, unsafe living conditions.This is where Galaxy Plumbing & Heating steps in. As Vancouver's leading emergency plumbing services provider, Galaxy Plumbing is more than just a service provider—they are your first line of defense against plumbing disasters. "At Galaxy Plumbing & Heating, we understand how stressful and overwhelming a plumbing emergency can be," says Roger Mak, owner of Galaxy Plumbing & Heating. "Our mission is to provide fast, reliable, and professional plumbing service for our customers during these critical situations." Known for their unmatched reliability, rapid response, and deep expertise, Galaxy Plumbing & Heating is available when the unexpected happens; you have a trusted plumber ready to restore order swiftly and efficiently.The Critical Need for Emergency Plumbing ServicesPlumbing emergencies can strike at any time, often without warning, and the consequences can be severe if not addressed promptly. Common issues like burst pipes, gas leaks, and severely clogged drains may start as minor inconveniences but can quickly escalate into major problems. Water from a burst pipe can cause extensive damage to your home's structure, while gas leaks pose serious health risks and potential fire hazards."When a plumbing emergency occurs, time is of the essence," emphasizes Roger. "The longer you wait, the more damage can occur, so we prioritize emergency calls to show up on-site as quickly as possible." When it comes to plumbing emergencies, timing is everything. The longer you wait to address an issue, the more damage it can cause. Water damage, for instance, can lead to mold growth, structural weakening, and ruined personal belongings. Similarly, a gas leak requires immediate attention to prevent dangerous exposure or explosions. This is why having access to a reliable emergency plumbing service is so important—quick action can mean the difference between a minor repair and a costly restoration project.At Galaxy Plumbing & Heating, they understand the urgency of these situations. "We offer 24/7 emergency plumbing services throughout Metro Vancouver because we know that emergencies don't wait for business hours," says Roger. Their Vancouver plumbers are always ready to respond, whether it's the middle of the night, a weekend, or a holiday. They prioritize emergency calls to help their customers receive the help they need when they need it most. With Galaxy Plumbing, you're never alone during a plumbing crisis—they're just a phone call away, ready to provide swift and professional assistance.What Sets Galaxy Plumbing & Heating Apart?Not all emergency plumbing service providers are created equal. Galaxy Plumbing & Heating stands out in Vancouver for several reasons, making it the preferred choice for homeowners and businesses facing unexpected plumbing crises.First and foremost, expertise and experience are at the core of Galaxy Plumbing's service. "We pride ourselves on the extensive experience our team brings to every job," says Roger. "Our plumbers are skilled and continuously trained to handle all our challenges." This extensive experience means they can quickly diagnose problems and implement effective solutions, no matter how complex the issue. In addition, their commitment to continuous learning gives customers the very best service, even in the most challenging situations.Another distinguishing feature of Galaxy Plumbing is its rapid response times. In an emergency, every minute counts, and Galaxy Plumbing understands this better than anyone. The company has established efficient protocols to prioritize and handle emergency calls immediately. "When you call us, you can expect us to be there quickly, fully equipped to handle the issue," says Roger. "Our goal is to prevent minor problems from becoming major disasters." Their commitment to swift service means that when you call Galaxy Plumbing, you can expect a plumber to arrive at your doorstep as quickly as possible, fully equipped to address the issue. This quick action often prevents minor problems from turning into major disasters, saving customers time and money.Galaxy Plumbing & Heating distinguishes itself through its expertise and rapid response, making it the ideal choice for emergency plumbing services in Vancouver.Comprehensive Emergency Services OfferedWhen a plumbing emergency strikes, it’s important to have a service provider that can handle various issues quickly and effectively. Galaxy Plumbing & Heating offers a comprehensive suite of emergency services designed to address the most common and most challenging plumbing problems that homeowners in Vancouver might face.Range of Services Include:Burst Pipe Repair:Burst pipes can cause extensive water damage in a very short time. Their Vancouver plumbing company is equipped to handle burst pipes swiftly, minimizing water damage and restoring your plumbing system to proper working order. "Our plumbers quickly locate the source of the burst, repair the damaged section, and secure the rest of your plumbing system," explains Roger.Gas Leak Detection and Repair:Gas leaks are among the most dangerous plumbing emergencies, requiring immediate attention. Galaxy Plumbing’s technicians are highly trained in detecting and repairing gas leaks for your home’s safety. "We will locate gas leaks and make the necessary repairs for our customer's safety," says Roger.Clogged Drain Solutions:A clogged drain can escalate from a minor inconvenience to a full-blown emergency, especially if it leads to flooding. Galaxy Plumbing & Heating offers thorough drain cleaning services, using tools like high-pressure jetters to clear even the most stubborn clogs. Their expertise ensures that your drainage system remains efficient and problem-free.Heating System Repairs:During colder months, a malfunctioning heating system can quickly become an emergency. Galaxy Plumbing & Heating specializes in repairing and maintaining heating systems, including boilers and furnaces. "Keeping your home warm and comfortable, even when unexpected issues arise, is our priority," adds Roger.Water Heater Services:A sudden water heater failure can be more than inconvenient—it can disrupt your daily routine. Galaxy Plumbers offers emergency repair services for water heaters, restoring hot water to your home quickly and efficiently. Whether a simple fix or a more complex issue, they have the expertise to get your water heater back in operation.Preventive Tips:While emergencies are often unavoidable, there are steps homeowners can take to reduce the risk of plumbing issues. Galaxy Plumbing & Heating advises regular maintenance of plumbing systems to catch potential problems before they become emergencies. "We always encourage our customers to take preventive measures, like insulating pipes in the winter and regularly inspecting gas lines and water heaters," suggests Roger. "A little maintenance can go a long way in preventing emergencies."Galaxy Plumbing & Heating also recommends that homeowners familiarize themselves with the location of their main water shut-off valve. In the event of a burst pipe, shutting off the water supply can prevent extensive damage while waiting for professional help.Comprehensive Coverage in Vancouver:Galaxy Plumbing & Heating proudly serves a wide area across Greater Vancouver, so residents in these communities can access top-tier emergency plumbing services whenever needed. "From North Vancouver to Richmond and Burnaby to Langley, we're committed to providing swift, reliable service to keep your home safe and comfortable," says Roger.Galaxy Plumbing & Heating offers a full range of emergency plumbing services, from burst pipe repairs to gas leak detection; no matter the crisis, you’re in capable hands. By combining their comprehensive service offerings with preventive advice, they help homeowners manage emergencies and minimize the chances of them occurring in the first place.How to Reach Galaxy Plumbing & Heating in an EmergencyKnowing how to contact a reliable service provider quickly can make all the difference during a plumbing emergency. Galaxy Plumbing & Heating understands the urgency of such situations, so they’ve made it easy for Vancouver residents to get in touch, day or night.Your Vancouver Plumber of Choice During Times of EmergencyIf you have a plumbing emergency, don’t hesitate—Galaxy Plumbing & Heating is just a phone call away. "We’re always ready to help, no matter the time of day," says Roger. Their dedicated emergency line helps you reach a qualified plumber anytime during regular business hours, late at night, or even on weekends and holidays. Dial (604) 802-1518 and call our plumber to schedule an appointment.Galaxy Plumbing offers a quick and easy online service request form on its website for those who prefer online communication. You can submit your details, and a plumber will contact you immediately. This option is particularly useful for non-urgent issues or when you cannot call.In an emergency, every second counts. Trust Galaxy Plumbing & Heating to be your first call so that your home remains safe, secure, and comfortable, no matter what plumbing challenges you face. Media Contact Organization: Galaxy Plumbing & Heating Contact Person: Roger Mak Website: https://galaxyplumbingservices.com/ Email: Send Email Contact Number: +16048021518 Address:5307 Victoria Dr #1180, Vancouver, BC V5P 3V6 City: Vancouver State: BC Country:Canada Release id:15496

AIPACTEX Sets New Standards in Decentralized Finance with Innovative Trading Platform

AIPACTEX, a pioneer in decentralized finance, has rapidly gained recognition in the cryptocurrency market with its advanced decentralized exchange (DEX). Colorado, United States, 9th Aug 2024 - Driving Innovation with Advanced Technology: AIPACTEX leverages cutting-edge Starlink technology to optimize its Automated Market Maker (AMM) model, significantly enhancing transaction efficiency and reducing Gas fees. This innovation supports a dynamic range of features including virtual space games, NFT auctions, and the trading of virtual assets, which cater to a diverse user base interested in both traditional trading and novel blockchain experiences.AIPACTEX V5: Empowering Users with Flexibility and ControlWith the launch of AIPACTEX V5, the platform has introduced enhanced functionalities that provide liquidity providers with increased compensation, control, and flexibility. This update reflects AIPACTEX’s commitment to improving user experience and fostering an environment where both traders and liquidity providers can thrive. Ensuring Fair and Secure Trading"AIPACTEX is committed to promoting a fair trading environment and true decentralization in the DeFi sector," said Liam Michael Walsh, spokesperson for AIPACTEX. "Our platform is designed to provide all users, regardless of their location or experience level, with equal opportunities to engage in and benefit from the growth of decentralized finance." Comprehensive Cryptocurrency SupportAIPACTEX supports a broad array of cryptocurrencies, including BTC, ETH, BCH, and others, offering features. Its intuitive interface ensures that both new and experienced traders can navigate and execute trades effectively, benefiting from one of the most competitive fee structures in the market. Invitation to Experience AIPACTEXCryptocurrency traders and blockchain enthusiasts are encouraged to explore the unique features and opportunities available at AIPACTEX. For more information or to begin trading, please visit https://aipactex.com/.About AIPACTEXLocated in New York City, AIPACTEX is at the forefront of the decentralized finance industry, offering a comprehensive suite of services designed to enhance the trading experience. The platform combines innovative technology with a user-centric approach to stay ahead in the rapidly evolving cryptocurrency market. Media Contact Organization: AIPACTEX Contact Person: LIAM MICHAEL WALSH Website: https://aipactex.com/ Email: Send Email City: Colorado Country:United States Release id:15482

IKAR Holdings Launches IKAR Crypto Ventures

  United Kingdom, 9th Aug 2024, Grand Newswire – IKAR Holdings, a prominent multi-tiered entrepreneurial group based in London, has announced the incorporation of IKAR Crypto Ventures, marking a significant entry into the cryptocurrency market despite ongoing global market turbulence. Recognizing the current volatility affecting cryptocurrencies, IKAR Holdings has decided to enhance its engagement and amplify its activities within the industry. The new subsidiary, IKAR Crypto Ventures, aims to consolidate the group’s initiatives in the Fintech and Blockchain sectors under a unified operational framework. With strategic holdings in Bitcoin Hotels, the launch of the world’s first Crypto Space Bank, and a partnership with Swiss-Japanese technology firm Unify Platform AG, IKAR Crypto Ventures is already positioned to make impactful strides in the market. The overarching mission of IKAR Crypto Ventures is to cultivate exceptional business opportunities and investments in real assets, leveraging financial vehicles backed by cryptocurrency. The new holding will focus on diverse projects and investment avenues ranging from education and hospitality to real estate, sports, health, and technology. This approach will utilize the extensive portfolio and pipeline that IKAR Holdings has developed over the years. Moreover, IKAR Crypto Ventures aims to create a global ecosystem for crypto investors who share a common entrepreneurial vision. Orkun IBAK, the newly appointed CEO and Partner of IKAR Crypto Ventures, expressed enthusiasm for the group’s ambitious vision:  “We do not merely follow the market trends. Instead, we carefully curate business opportunities, choosing to enter markets that may be facing challenges yet present substantial growth prospects. Particularly in the crypto sector, we perceive significant potential for growth by leveraging our extensive entrepreneurial experience and network.” Orkun IBAK highlighted the promising trajectory for the Unify Platform Token (UPT), stating, “We are optimistic about UPT’s performance and anticipate that its value will continue to rise throughout this year and into 2025. With the ongoing development of UPT, we foresee sustained engagement that will support the token’s value.” IKAR Crypto Ventures predicts an average price of $100 for UPT in Q1 2025, which reflects a potential 10x increase from its current value. “We have laid the groundwork for extraordinary growth in the coming years, and we are committed to incorporating exceptional projects into our portfolio,” he added. The Unify Platform Token (UPT) is set to be listed on Probit Global, with upcoming listings on Whitebit and Tokenize Xchange. The Future of Bitcoin: Insights and Price Predictions Bitcoin remains a focal point in the cryptocurrency market, particularly amid the recent volatility that has captured the attention of investors and analysts alike. Orkun IBAK stated with bold predictions suggesting that Bitcoin could soon reach a price range between $90,000 and $95,000, an anticipated increase of approximately 60% from its current trading level of $58,885 is on the table. This forecast signifies a potential recovery trajectory, highlighting the resilience of Bitcoin despite the challenges posed by recent downturns and market liquidations. Factors Driving the Potential Surge Several key elements are influencing the optimistic outlook for Bitcoin’s price. One of the most critical factors is the resistance levels that Bitcoin must break through to sustain its bullish momentum. Successfully overcoming these barriers will be paramount for ensuring continued growth in the crypto space. Additionally, market sentiment is trending toward optimism, reflecting an increasing belief in Bitcoin’s ability to rebound and advance. However, it is important to recognize the speculative nature of cryptocurrencies, which inherently comes with high volatility and risk. Investors must approach the market with this understanding in mind. For investors looking to navigate this complex landscape, the prospect of significant gains is tantalizing, but it comes hand-in-hand with inherent risks and uncertainties. Vigilance is essential, as market participants must weigh the potential rewards against the unpredictable nature of cryptocurrency investments. Adding another layer to this discussion is the observation regarding Bitcoin’s performance heading into Q4 2024. The $50,000 range has emerged as a critical support level. Analysts suggest that Bitcoin’s recent dip may serve as a foundation for a substantial rally. Observations of a long-term diagonal support line indicate that if Bitcoin can maintain consolidation at these support levels, we could be poised for a significant breakout as we approach 2025. Long-Term Outlook: Signs of Robustness As we look ahead, the long-term outlook for Bitcoin appears increasingly positive. Recent periods of stability and minor corrections could be viewed as essential consolidating phases for building momentum. The growing institutional interest in cryptocurrencies, coupled with the vigilant monitoring of critical support levels, fosters a sense of optimism about Bitcoin’s performance in the coming months. Nonetheless, it is paramount for investors to stay informed and consider a combination of technical analyses and broader market trends when crafting their investment strategies. Bitcoin traverses this unpredictable landscape, it is imperative that investors remain aware of the dynamic market conditions that influence price movements. With valuable insights emerging from market analysis, the ability to adapt to changing trends will be crucial for making informed decisions in the exhilarating world of cryptocurrency. Media Contact Organization: IKAR HOLDINGS Contact Person: Michael Bert Website: https://ikarholdings.com/ Email: Send Email Address: 17 Savile Row, London W1S 3PN City: LONDON State: MAYFAIR Country: United Kingdom Release Id: 09082415490 The post IKAR Holdings Launches IKAR Crypto Ventures appeared on King Newswire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

Your Health in Your Hands: Early Screening and Intervention for Colorectal Cancer Improves People’s Lives

Colorectal cancer is the third most common cancer worldwide and the second leading cause of cancer-related deaths. It usually develops slowly over 5-10 years, so early detection can significantly improve treatment outcomes and reduce mortality rates. National screening programs in China, Australia, and the U.S. demonstrate the positive impact of early screening. In July 2024, Australia lowered the screening age from 50 to 45, emphasizing early detection as cancer rates rise among those under 50. Advances in non-invasive tests, such as #BGI's DNA methylation testing, offer easier and effective options. It is by taking action now and by using the latest tests to identify colorectal cancer at an early stage that can have the greatest impact on people’s lives, today. China, 9th Aug 2024 - In July 2024 Australia lowered the entry age for its National Bowel Cancer Screening Program from 50 to 45 and became the latest country to recognize that the early detection of colorectal cancer can have a significant impact on people’s lives, especially with cancer rates rising among Australians under 50. From 1982-2014 the incidence of bowel cancer increased 9% for those under 50. Colorectal cancer is the third most common cancer worldwide and the second leading cause of cancer-related deaths. However, colorectal cancer usually develops slowly over a period of 5-10 years which means that early detection can make a very real difference in terms of treatment and mortality rates.Yet, despite many countries implementing national screening programs, by 2040 the burden of colorectal cancer is projected to increase to 3.2 million new cases and 1.6 million deaths per year representing a 66% and 71% rise in new cases and deaths, respectively, relative to 2020.More action is needed to persuade people to undergo screening and at an earlier age. However, as BGI identified in its 2024 Global State of Colorectal Cancer Awareness Report, there is a significant gap around the world in awareness of and accessibility to screening programs, with the main barriers to screening being cost and fear.For many people cancer is a stigma and a highly emotional topic. Most will have known relatives or friends who died from cancer and there is a fear both around being diagnosed with the life-threatening disease and fear of the detection process itself. While colonoscopy is considered the gold standard by doctors for cancer detection, it is invasive and requires both fasting and purging that deters many people from being screened until the disease has developed beyond its early stages, significantly reducing life expectancy rates.Another widely used test in colorectal screening is fecal immunochemical testing (FIT). This is a stool test that detects hidden blood in the stool which can be a sign of precancerous polyps or colorectal cancer. However, as a screening method FIT has limitations in terms of when the sample can be collected and has a low (11%-29%) detection rate for pre-cancer or early-stage adenomas polyps as well as a high false positive rate.Advances in detection methods have resulted in a new test that undertakes non-invasive DNA methylation of a stool sample to detect colorectal cancer. Methylation is a biological process in which a small molecule called a methyl group is added to DNA. This can have several impacts including inhibiting the gene, leading to diseases such as a cancers. If the result is positive for biomarkers, a colonoscopy can be performed for more detailed diagnosis. This is easier for people to use and does not have the limitations of FIT testing, nor the expense of a colonoscopy unless one is really needed.  BGI’s COLOTECT test is one of the DNA methylation tests widely available for colorectal cancer. While the screening frequency for FIT is annually, stool DNA tests only need to be performed every three years if the test result is normal. COLOTECT uses multiplex methylation-specific PCR technology to trace abnormal DNA methylation markers in colorectal cancer from stool samples. It has 88% colorectal cancer sensitivity in early detection, which is important since colorectal cancer develops slowly and may not be detected at an early stage when treatment can be more effective.China has a high rate of bowel cancer with the incidence increasing among those under 50. In 2021-2022 Wuhan implemented a colorectal cancer screening study for people aged 45-60. 98,683 people participated in fecal DNA methylation testing with 4.5% screening positive and leading to colonoscopy diagnosis findings in 2,347 people. This indicates the effectiveness of the fecal DNA methylation test.In Harbin, an extensive free screening project was launched in March 2024 for 800,000 eligible permanent residents aged 45-64. Powered by the newly established BGI-Heilongjiang Omics Health Axis Intelligent Laboratory (BGI-HL OHA Intelligent Laboratory), the first phase of the screening project uses BGI's fecal DNA methylation testing to assess the risk of colorectal cancer and advanced adenomas. Apart from colorectal cancer, this project also screening for hypoglycemia, hyperlipidemia, and hypertension. Large scale public health projects such as these in Harbin and Wuhan are good test cases for the rest of the world on what mass testing can achieve.National screening programs are certainly helping to improve the detection of colorectal cancer. The U.S. began to promote non-invasive cancer screening much earlier than other countries, and with the introduction of new screening technologies and the continuous improvement of screening coverage, the incidence and mortality rate of colorectal cancer in the U.S. has steadily declined.Australia’s National Bowel Cancer Screening Program was implemented in 2006, based initially on FIT testing and this has led to the screening age range expanding over time to 50-70 years old and now to 45-74 years old. This has resulted in a drop in mortality from bowel cancer from 44.1/100,000 people in 2006 to 29.8/100,000 people in 2018, and a further decline to 23/100,000 people is expected in 2024.The expansion of the screening age to 45 years by many countries will undoubtedly bring widespread positive health benefits and help improve overall cancer management and preventative strategies. At the same time, the advances in detection testing also make it more readily acceptable for people to be willing to be tested and earlier detection leads to earlier treatment and a greater likelihood of effective treatments. Together, these advances promise to make colorectal cancer a more manageable condition and much less life-threatening.The burden on families and societies of cancer can be enormous. Finding a cure is in many ways the holy grail of scientific research. Cancer evolution and development is extensively studied by scientists globally using the latest high-throughput genome sequencing to undertake detailed analysis of DNA coding region mutations leading to colorectal cancer.   In one of the latest studies published recently by Nature, BGI, Uppsala University and other collaborators, undertook the largest integrated genome and transcriptome analysis of colorectal cancer to date, providing ground-breaking insights that could lead to more personalized and effective treatments for colorectal cancer. While every scientific study leads to an advance in knowledge, it is by taking action now and by using the latest tests to identify colorectal cancer at an early stage that can have the greatest impact on people’s lives, today. Source:Lowered eligible age for bowel screening. Australian Government Department of Health and Aged Care. https://www.health.gov.au/our-work/national-bowel-cancer-screening-program/about-the-national-bowel-cancer-screening-program/lowered-eligible-age Trends in Colon and Rectal Cancer Incidence in Australia from 1982 to 2014: Analysis of Data on Over 375,000 Cases. Cancer Epidemiology, Biomarkers & Prevention. https://aacrjournals.org/cebp/article/28/1/83/71847/Trends-in-Colon-and-Rectal-Cancer-Incidence-in Colorectal cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer BGI Genomics 2024 Global State of Colorectal Cancer Awareness Report. BGI Genomics. https://www.bgi.com/global/news/bgi-genomics-2024-global-state-of-colorectal-cancer-awareness-report BGI-HL OHA Laboratory Opens in Harbin, Providing Colorectal Cancer Risk Evaluation for 800,000. BGI Genomics. https://www.bgi.com/global/news/bgi-laboratory-opens-in-harbin-providing-colorectal-cancer-risk-evaluation Sweden’s Uppsala University and BGI Group Jointly Publish the World’s Largest Multi-Omics Study on Colorectal Cancer. BGI Group. https://en.genomics.cn/en-news-275-6977.html   Media Contact Organization: BGI Group Contact Person: Richard Li Website: https://en.genomics.cn/ Email: Send Email Country:China Release id:15468